A method for designing an instrument for orthopedic surgery includes obtaining imaging information associated with a bone segment of a subject and an implant fastened to the bone segment, creating a bone segment model and an implant model based on the imaging information associated with the bone segment and the implant, and generating information regarding a shape of an instrument based on the bone segment model and the implant model. The instrument is to be disposed on the bone segment and the implant. The instrument is formed with a path to align a positioning component with a location of the bone segment which is not covered by the implant and at which the positioning component is to engage the bone segment.