Describing has and SEQ ID NO：3 sequence have at least 98% homogeneity or with SEQ ID NO：The AAV capsid proteins of the 4 sequence at least amino acid sequence of 94% homogeneity.A kind of pharmaceutical composition is also described, AAV capsids and virion comprising the capsid protein, restructuring AAV carriers and the host cell comprising the capsid protein or the carrier and transgenic animals comprising the nucleotide sequence for encoding the capsid protein.In addition, also describing the method being transferred to purpose nucleic acid in mammal, it includes that AAV vector introduction mammals will be recombinated, and wherein restructuring AAV carriers include the target gene being wrapping in the capsid comprising the capsid protein.Buluş, adeno-ilişkili virüs (AAV) kapsid varyantları ile ilgilidir.
