#$%^&*AU2015200009A120150129.pdf#####P: OPER HRB Eservces 35229616 35229616 ABSTRACT.docx-2/01/2015 ABSTRACT An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer； a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract； and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.WO 2009/023672 PCT/US2008/072914 FIGURE 1 Abuse-Resistant Oxycodone Tablet (Preferred Example) Comparative in-vitro Release Rate in DI Water；100 RPM； Basket； 900 mL Intact tablet vs. Grinded tablet 100 90 70 S50 -F nftact 30- 20 0' 0 E 10 15 20 25 Time (hours)
