The Trustees of the University of Pennsylvania;Novartis AG
发明人:
Jennifer Brogdon,Saar Gill,David Jonathan Glass,Saad Kenderian,Andreas Loew,Joan Mannick,Michael Milone,Leon Murphy,David L. Porter,Marco Ruella,Yongqiang Wang,Qilong Wu,Jiquan Zhang
申请号：
US15726703
公开号：
US20180312595A1
申请日:
2017.10.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
