Method for Inhibition of Deubiquitinating Activity

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专利权人:

发明人:

Stig Linder,Rolf Larsson

申请号：

US14256280

公开号：

US20140228354A1

申请日:

2014.04.18

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Compounds of the general structure S-1, wherein X and R1-R5 are defined in the specification, are capable of abrogating the deubiquitinating (DUB) activity of the 19S RP DUBs and are useful in methods and compositions for treating cancer, in particular, cancer tumors refractory to treatment by state-of-the-art chemotherapy.

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