The present invention relates to a compound of the formula Iwherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin； the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin； the use of a compound of that class in the treatment of a disease that depends on activity of renin； pharmaceutical formulations a compound of that class； a method of treatment comprising administering a compound of that class and a method for its manufacture.本發明係關於一種式I化合物：其中R1、R2、R3、R4及R5係如說明書中所定義，其係用於診斷性及治療性處理溫血動物，尤其用於治療與腎素活性相關之疾病(=病症)；彼類化合物用於製備用以治療與腎素活性相關之疾病的醫藥調配物之用途；彼類化合物在治療與腎素活性相關之疾病中之用途；包含彼類化合物之醫藥調配物；包含投與彼類化合物之治療方法及彼類化合物之製造方法。
