The present invention relates to therapeutic methods, uses and compositions comprising CCBE1 and VEGF-C for treating disorders and conditions involving impaired lymphatic system, particularly lymphedema.本發明有關於用於治療涉及受損淋巴系統的疾病與狀態之治療方法、用途以及組合物,其包括CCBE1與VEGF-C,其中受損淋巴系統特別係指淋巴水腫。