General system< Conversion 1 >In formula, as for R1, the amijino basis which is possible to be substituted with the hydroxyl basis which is possible to be protected with the acyl basis, the amijino basis which is possible to be substituted with the alkoxy group which is possible to be substituted or the amijino basis which is possible to be substituted with the Al alkyl oxy basis which is possible to be substituted R2 and R3, equality or differing, shows the hydrogen atom or the halogen atom.So the medicine composition which contains the anti- true germ medicine of one or more which from the aryl amidine derivative or that salt and the azole type anti- true germ medicine, the polyene type anti- true germ medicine, the kiyandein anti- true germ medicine and the fluoro pyrimidine anti- true germ medicine which are displayed is chosen has strong anti- true germ activity, it is useful in remedy of the true germ infection symptom, the method where it can combine these and uses is useful as a cure of the true germ infection symptom which is superior. In addition, the aryl amidine derivative or that salt of the above-mentioned general formula and the medicine composition which contains the immunity inhibiter have strong anti- true germ activity, it is useful in remedy of the skin disease such as true germ infection symptom and the atopic characteristic dermatitis, the method where it can combine these and uses is useful as the cure where the skin disease such as true germ infection symptom and the atopic characteristic dermatitis is superior.一般式【化1】「式中、R1は、アシル基で保護されてもよいヒドロキシル基で置換されてもよいアミジノ基、置換されてもよいアルコキシ基で置換されてもよいアミジノ基または置換されてもよいアルアルキルオキシ基で置換されてもよいアミジノ基を;R2およびR3は、同一または異なって水素原子またはハロゲン原子を示す。」で表されるアリールアミジン誘導体またはその塩ならびにアゾール系抗真菌剤、ポリエン系抗真菌剤、キャンディン系抗真菌剤およびフルオロピリミジン系抗真菌剤から選ばれる一つ以上の抗真菌剤を含有する医薬組成物は、強い抗真菌活性を有し、真菌感染症の治療に有用であり、これらを組み合せて使用する方法は、優れた真菌感染症の治療法として有用である。また、上記一般式のアリールアミジン誘導体またはその塩および免疫抑制剤を含有する医薬組成物は、強い抗真菌活性を有し、真菌感染症およびアトピー性皮膚炎などの皮膚疾患の治療に有用であり、これらを組み合せて使用する方法は、真菌感染症およびアトピー性皮膚炎
