This Wen Gong Open compound of formula I: or Ke receives Which or molten Elixirs and closes object or preceding Drug on Qi Li Body Iso Agencies Body, mutual Change Iso Agencies Body Huo Drug Learn, wherein R1, R2, Ra, Rb, Rc, Rd, X, Y, B with and Ring C such as this Wen Suoding Righteousness； And and the wherein part the Y-B and the part the NH-C (=X)-NH are in trans- Agencies type, the compound is that TrkA kinase inhibition Elixirs And Qie Fitness controls Treatment with what and can control the disease of Treatment with TrkA kinase inhibition Elixirs, such as pain, cancer, inflammation, mind The Change disease and certain infectious diseases.本文公開了式I化合物：或其立體異構體、互變異構體或藥學上可接受的鹽、或溶劑合物或前藥，其中R1、R2、Ra、Rb、Rc、Rd、X、Y、B以及環C如本文所定義，並且其中所述Y‑B部分和所述NH‑C(＝X)‑NH部分呈反式構型，所述化合物是TrkA激酶抑制劑並且適用於治療可以用TrkA激酶抑制劑治療的疾病，如疼痛、癌症、炎症、神經變性疾病以及某些感染性疾病。
