BOVIN, NICOLAI,WEINBERG, CRISTINA-SIMONA,HENRY, STEPHEN MICHEAL
申请号：
CA2699366
公开号：
CA2699366C
申请日:
2008.09.11
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Peptide-lipid constructs of the structure L-S-F are disclosed, where F is apeptide, S is a spacer covalently linking F toL via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideallyhas 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecularweight of approximately 250 to 600. Also disclosed isa method of detecting reactive antibodies in serum by contacting serum withcells modified to incorporate a peptide-lipid construct,where the peptide is an epitope of the antibody, and determining the degree ofagglutination of the cells.
