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Microspheres contenant des isotopes radioactifs therapeutiques et diagnostiques
专利权人:
BIOSPHERE MEDICAL; INC.
发明人:
申请号:
EP12193933.4
公开号:
EP2574347A3
申请日:
2004.03.08
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
One aspect of the present invention relates to a microsphere impregnated with a radioisotope that emits therapeutic ß-particles and a radioisotope that emits diagnostic gamma radiation; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, the microsphere is composed of glass impregnated with 90Y as the source of the therapeutic ß-emissions and 98Au as the source of the diagnostic gamma emissions. Another aspect of the present invention relates to the preparation of a microsphere impregnated with a radioisotope that emits therapeutic ß-particles and a radioisotope that emits diagnostic gamma radiation; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, a glass microsphere containing 90Y and 198Au is prepared by neutron activation of a glass microsphere comprising glass, 89Y and 197Au. Another aspect of the present invention relates to administration to a mammal of a therapeutically effective amount of microspheres impregnated with a ß-emitting radioisotope and a gamma emitting radioisotope; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In one preferred embodiment, said microspheres are administered to the patient through a catheter.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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