A tissue collection device and method. One embodiment of the device includes a body formed by an elongated member, a pair of inflatable balloons at spaced-apart locations on the body, and one or more collection structures on the body. Inflation lumens extending through the body and coupled to the balloons cause the balloons to move between collapsed and expanded states. The collection structures collect a tissue sample from a collection region between the balloons. In another embodiment the collection structures include one or more of an irrigation lumen and an aspiration lumen having one or more ports opening into the collection region.
