ALBERT ANTOLIN HERNANDEZ,CARME SERRA COMAS,ESTER MONLLEO MAS,JUAN LORENZO CATENA RUIZ,OSCAR REY PUIGGROS
申请号：
BRPI1012963
公开号：
BRPI1012963A2
申请日:
2010.06.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.
