Granule formation of pirfenidone and pharmaceutically acceptable excipients

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专利权人:

INC.;INTERMUNE

发明人:

RADHAKRISHNAN, RAMACHANDRAN,VLADYKA, RONALD,SULTZBAUGH, KENNETH

申请号：

NZ59144305

公开号：

NZ591443A

申请日:

2005.09.22

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

Disclosed is a granulate formulation of 5-methyl-1-phenyl-2-(1H)-pyridone (pirfenidone), wherein said granulate formulation comprises: 5-methyl-1-phenyl-2-(1H)-pyridone and pharmaceutically acceptable excipients, said excipients comprising an effective amount of an absorption-enhancing binder to increase the AUC of the 5-methyl-1-phenyl-2-(1H)-pyridone at least 45 per cent upon oral administration, as compared to pirfenidone without excipients orally administered in a capsule shell.

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