antibody-drug conjugate, pharmaceutical composition, methods for releasing an active agent, treating a disease, inhibiting tumor progression and inhibiting, decreasing or eliminating the metastatic capacity of a tumor, and, kit.
The present invention relates to uparap targeting conjugates, in particular antibody-drug conjugates (adcs) comprising monoclonal antibodies directed against the uparap n-terminal region, and their use in releasing active agents into uparap expressing cells and tissues. The invention further relates to the use of said ADCs in the treatment of diseases involving uparap expressing cells such as cancer.a presente invenção refere-se aos conjugados que alvejam uparap, em particular conjugados anticorpo-fármaco (adcs) compreendendo anticorpos monoclonais direcionados contra a região n-terminal de uparap, e seu uso na liberação de agentes ativos nas células e tecidos que expressam uparap. a invenção refere-se adicionalmente ao uso dos ditos adcs no tratamento de doenças envolvendo células que expressam uparap, tal como câncer.
