The present invention relates generally to the field of stem cells and, more particularly, to reprogramming blood cells to pluripotent stem cells. In a specific embodiment, a method for producing an induced pluripotent stem cell from a human myeloid progenitor cell comprising the steps of (a) activating the human myeloid progenitor cell by incubation with hematopoietic growth factors (b) transfecting the activated progenitor cells with a non-viral vector expressing one or more pluripotency factors and (c) co-culturing the transfected cells with irradiated mesenchymal bone marrow stromal cells.
