The present invention relates to hybrid nutritional supplement tablets for middle-aged adults and a method for manufacturing the same. Provided are the hybrid nutritional supplement tablets for middle-aged adults comprising: an active ingredient containing 0.5-5 wt% of vitamin A mixture, 0.04-0.4 wt% of vitamin B1 hydrochloride, 0.03-0.3 wt% of vitamin B2, 0.05-0.5 wt% of vitamin B6 hydrochloride, 5-15 wt% of vitamin C, 0.05-0.5 wt% of vitamin D mixture, 7-17 wt% of vitamin E mixture, 0.5-5 wt% of zinc oxide, and 0.1-1 wt% of manganese sulfate； diluting agents containing 40-60 wt% of one or two ingredients selected between microcrystalline cellulose and mixed lactose powder； 0.5-5 wt% of a coating agent； and other additives, and the method for manufacturing the same. According to the present invention, a health functional food containing various kinds of vitamins and minerals, and functional natural extracts is provided for the middle-aged adults, thereby providing the middle-aged adults, who are tired and stressed out due to excessive work, with vitamins and minerals so maintaining high metabolism and biological activity in the body, replenishing nutrients necessary for nerves, muscles, and skeletons to maintain their functions, enhancing the level of immunity and anti-oxidative function, also protecting a liver and improving liver function so overcoming physical fatigue, thus being helpful for the middle-aged adults to maintain healthy and vibrant life. [Reference numerals] (S10) Weighing step for weighing respective ingredients using an electronic scale； (S20) Mixing step for making a mixture by putting an active ingredient containing 0.5-5 wt% of vitamin A mixture, 0.04-0.4 wt% of vitamin B1 hydrochloride, 0.03-0.3 wt% of vitamin B2, 0.05-0.5 wt% of vitamin B6 hydrochloride, 5-15 wt% of vitamin C, 0.05-0.5 wt% of vitamin D mixture, 7-17 wt% of vitamin E mixture, 0.5-5 wt% of zinc oxide, and 0.1-1 wt% of manganese sulfate and a diluting agent containing 40-60 wt%
