THE UNIVERSITY OF BRITISH COLUMBIA;TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人:
DUKSIN, CHEN,TESSLER, SHOSHI,GLEAVE, MARTIN
申请号：
CA2836676
公开号：
CA2836676A1
申请日:
2012.05.18
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A method of treating a human patient afflicted with lung cancer comprising periodically administering to the human patient chemotherapy comprising an amount of a taxane and 640mg of an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti- clusterin oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2 ' -O-methoxyethyl modifications, has nucleotides 5-17 which are 2 ' deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19, thereby treating the human patient afflicted with cell lung cancer.
