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Carbamate / urea derivatives
专利权人:
Novartis AG
发明人:
AUBERSON, Yves,BOCK, Mark Gary,BRAGA, Dario,CURZI, Marco,DODD, Stephanie Kay,GIAFFREDA, Stefano Luca,JIANG, Haiyang,KARPINSKI, Piotr,TROXLER, Thomas J.,WANG, Tielin,WANG, Xiaoyang,ZHANG, Xuechun
申请号:
ES13770709
公开号:
ES2648512T3
申请日:
2013.07.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of the formula I ** Formula ** or a salt thereof, wherein R 1 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 5-6 cycloalkenyl or C 3- cycloalkyl 6-C1-4 alkyl; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-6 cycloalkyl-C1-4 alkyl alkyl may be substituted once or more than one by halogen; and wherein said C3-6 cycloalkyl or C5-6 cycloalkenyl may be substituted once or more than one by halogen, C1-4 alkyl or C1-4 halogenalkyl; m is 1 or 2; n is 0, 1, 2, 3 or 4; each R2 is independently halogen, hydroxyl, amino, cyano, nitro, C1-6 alkyl, halogenalkyl C1-6, hydroxyalkyl C1-6, alkoxy C1-4-alkyl C1-6, amino-alkyl C1-6, alkyl C1-4 -amino-C 1-6 alkyl, di (C 1-4 alkyl) - amino-C 1-6 alkyl, C 1-6 alkoxy, C 1-6 halogenalkoxy, C 1-6 alkylamino, di (C 1-6 alkyl) amino, C 2- alkenyl 6, C2-6 halogenalkenyl, C2-6 alkynyl or C2-6 halogenalkynyl; or C3-6 cycloalkyl, in which a carbon atom can be replaced by an oxygen atom, in which the C3-6 cycloalkyl can be attached directly to methylene or through a C1-2 alkylene, and in which the cycloalkyl C3-6 may be substituted once or more than one by halogen; or two R2 to the same carbon atom together with said carbon atom, a C3-6 cycloalkyl; X1 is oxygen or -N (R4) -; R4 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, or C3-6 cycloalkyl-C1-2 alkyl; p is 1 and q is 1; p is 0 and q is 1; or p is 0 and q is 0; r is 0, 1, 2, 3 or 4; each R3 is independently halogen, hydroxyl, amino, cyano, nitro, C1-6 alkyl, halogenalkyl C1-6, hydroxyalkyl C1-6, alkoxy C1-4-alkyl C1-6, amino-alkyl C1-6, alkyl C1-4 -amino-C 1-6 alkyl, di (C 1-4 alkyl) -amino-C 1-6 alkyl, C 1-6 alkoxy, C 1-6 halogenalkoxy, C 1-6 alkylamino, di (C 1-6 alkyl) amino, C 2- alkenyl 6, C2-6 halogenalkenyl, C2-6 alkynyl or C2-6 halogenalkynyl; or C3-6 cycloalkyl, in which a carbon atom can be replaced by an oxygen atom, in which the C3-6 cycloalkyl can be attached directly to methylene or through a C1-2 alkylene, and in which the cycloalkyl C3-6 may be
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