Methods of blocking or modulating the palmitoylation of NRAS or other RAS proteins useful in the treatment of cancer are provided, as are methods for identifying and/or characterizing such agents. In addition, methods for identifying and/or characterizing patient populations responsive to the particular agents are provided.Linvention concerne des agents utiles dans le traitement du cancer, ainsi que des systèmes permettant didentifier et/ou de caractériser de tels agents et des systèmes permettant didentifier et/ou de caractériser des populations de patients répondant à des agents particuliers.