This invention includes the amino acid arrangement which is displayed with the below-mentioned general formula 1, epidermal growth factor (EGF) regards peptide and its use which show activity. [General system 1] Cys Met Tyr Ile Glu linker Arg Gly Asp As for the EGF mimicry peptide of this invention, it is possible, the natural self secretion (autocrine) to do function or the action which is identical with natural person EGF it is possible inside the cell to promote the formation of EGF. In addition, the peptide of this invention stability is very high by comparison with nature EGF, is superior very to skin permeability. Therefore, the composition which includes the peptide of this invention can remedy the disease or a state where EGF activity is required, showing the effect which is superior very it makes prevent or improves, or in, can apply to the item and the cosmetics outside the medicine and the medicine very profitably.< Selective figure >Figure 7本発明は、下記の一般式1で表されるアミノ酸配列を含み、上皮細胞成長因子(EGF)活性を示すペプチド及びその用途に関する。[一般式1]Cys-Met-Tyr-Ile-Glu-リンカー-Arg-Gly-Asp本発明のEGFミミックペプチドは、天然のヒトEGFと同一な機能または作用をすることができ、細胞内で天然の自己分泌(autocrine)EGFの生成を促進することができる。また、本発明のペプチドは、安定性が天然EGFと比較して非常に高く、皮膚透過度に非常に優れている。したがって、本発明のペプチドを含む組成物は、EGF活性が要求される疾患または状態を治療、予防または改善するにおいて、非常に優れた効能を発揮して、医薬、医薬外品及び化粧品に非常に有利に適用できる。【選択図】図7
