TRAITEMENT DU CANCER DU SEIN TRIPLE NEGATIF OU DU CANCER COLORECTAL COMPORTANT DES METASTASES HEPATIQUES PAR UN ANTICORPS ANTI-PD-L1 ET UN VIRUS ONCOLYTIQUE
GANSERT, JENNIFER LORRAINE,BHATTA, SUMITA SHANKAR,WOODARD, JOSEPH PAUL,CHA, EDWARD
申请号：
CA3071599
公开号：
CA3071599A1
申请日:
2018.08.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Provided herein are methods of treating a subject with triple negative breastcancer or colorectal cancer. In exemplaryembodiments, the method comprises administering to the subject a combinationof an oncolytic virus, such as talimogene laherparepvec,and an anti-PD-Ll antibody, such as atezolizumab. In exemplary aspects, theoncolytic virus is administered to the subject at an initialdose followed by a second dose, wherein the initial dose is lower than thesecond dose. In exemplary aspects, the oncolytic virus isintrahepatically administered to the subject.
