The Board of Trustees of the Leland Stanford Junior University
发明人:
SAKAMOTO, Kathleen Miho,SMITH, Mark,CHAE, Hee-Don,MITTON, Bryan,COX, Nicholas Raymond
申请号：
EP17764254
公开号：
EP3426632A4
申请日:
2017.03.10
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Compounds and methods are provided for inhibiting a CREB-CBP protein-protein interaction in a sample. In some cases, the method includes modulating transcription of CREB in a cell that overexpresses CREB. Also provided are methods of inhibiting the proliferation of a cancer cell. The subject CREB transcription inhibitor compounds include a substituted salicylamide or a prodrug thereof. Methods of alleviating symptoms associated with cancer (e.g., Acute Myeloid Leukemia (AML) or Acute Lymphomblastic Leukemia (ALL)) in a subject in need thereof are also provided. Pharmaceutical compositions including the subject compounds find use in treating cancer. The subject compounds may be formulated or provided to a subject in combination with a second agent, e.g. an anticancer agent.
