Bacon, Elizabeth,Balan, Gayatri,Chou, Chien-Hung,Clark, Christopher,Cottell, Jeromy J.,Kim, Musong,Kirschberg, Thorsten A.,Link, John O.,Phillips, Gary,Schroeder, Scott D.,Squieres, Neil H.,Stevens, K
申请号：
CU20170172
公开号：
CU20170172A7
申请日:
2016.06.30
申请国别(地区):
CU
年份:
2018
代理人:
摘要：
<；p>； This description generally refers to substituted 4,6-diaminoquinolin-3-carbonitriles, of formula I which are modulators of Cot (Osaka thyroid cancer). <；/p>； <；p>； SPACE FOR FORMULA <；/ p>； <；p>； Pharmaceutical compositions and manufacturing methods of substituted 4,6-diaminoquinolin-3-carbonitriles are provided which are useful in analgesic, antipyretic or anti-inflammatory and antineoplastic therapies. <；/p>；<；p>；La presente descripción se refiere en general a 4,6-diaminoquinolin-3-carbonitrilos sustituidos, de fórmula I que son moduladores de Cot (cáncer de tiroides Osaka).<；/p>； <；p>；ESPACIO PARA LA FÓRMULA<；/p>； <；p>；Se proporcionan composiciones farmacéuticas y métodos de fabricación de 4,6-diaminoquinolin-3-carbonitrilos sustituidos que son útiles en terapias analgésicas, antipiréticas o antiinflamatorias y antineoplásicas.<；/p>；
