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Glypican-3 (GPC3) -derived cancer rejection antigen peptide for HLA-A2 positive person and pharmaceutical containing the same
专利权人:
オンコセラピー・サイエンス株式会社
发明人:
西村 泰治,中面 哲也,小森 宏之
申请号:
JP2007529588
公开号:
JP5299942B2
申请日:
2006.08.08
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.
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