RUF, SVEN,PERNERSTORFER, JOSEF,SADOWSKI, THORSTEN,HORSTICK, GEORG,SCHREUDER, HERMAN,BUNING, CHRISTIAN,WIRTH, KLAUS
申请号：
HRP20160047
公开号：
HRP20160047T1
申请日:
2016.01.15
申请国别(地区):
HR
年份:
2016
代理人:
摘要：
3-Heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula I, wherein Ht, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
