The preset invention provides a method of increasing the effect of an activated potentiated form of an antibody to an endogenous biological molecule by combining said endogenous biological molecule with an activated potentiated form of an antibody to endothelial NO synthase. The present invention also provides a pharmaceutical composition comprising a) an activated potentiated form of an antibody to an endogenous biological molecule and b) an activated potentiated form of an antibody to NO synthase.