The system has a lancet guide for guiding a lancet holder (20), and a lancet drive (30) comprising an elastic drive element (31). A tensioning and trigger device has an operating element (40) accessible from an outer side of a housing (10). The trigger device has a locking device that is mechanically coupled with the operating element and the lancet drive such that the lancet drive is tensioned and triggered during movement of the operating element along an operating path, where the triggering of the lancet drive is enabled during reaching of a predetermined point along the path.