The present invention relates to a composition comprising at least one MAPK pathway inhibitor comprising a MEK inhibitor and a RAF inhibitor and at least one PI3Kβ inhibitor, as well as its use for the treatment of cancer.本発明は、MEK阻害剤およびRAF阻害剤を含む少なくとも1つのMAPK経路阻害剤ならびに少なくとも1つのPI3Kβ阻害剤を含む組成物に関し、ならびに癌の処置のためのその使用にも関する。