BEHRENS, CHRISTIAN,GILLES, JEAN GUY G.,JACQUEMIN, MARC G.,SAINT-REMY, JEAN-MARIE R.
申请号:
PL05292669
公开号:
PL1749537T3
申请日:
2005.12.14
申请国别(地区):
PL
年份:
2012
代理人:
摘要:
A monoclonal antiidiotypic antibody (Ab1), against a human antibody (Ab2) that inhibits factor VIII (F8) and is directed to the A2 domain of F8, is new. Independent claims are included for: (1) a stable cell line that produces Ab1; (2) hybridoma 30D1 (CNCM I-3450); (3) a DNA fragment of 461 base pairs (bp; SEQ ID NO: 1), encoding the variable region of the heavy chain of Ab1; and (4) a DNA fragment of 431 bp (SEQ ID NO: 2), encoding the variable region of the light chain of Ab1. ACTIVITY : Hemostatic. No details of tests for hemostatic activity are given. MECHANISM OF ACTION : Inactivation of inhibitory autoantibodies against F8.