CARMELIDA CAPALDI,ROBERT ANDREW HEALD,NICHOLAS CHARLES RAY,JONATHAN MARK SUTTON
申请号：
ARP130102470
公开号：
AR091737A1
申请日:
2013.07.11
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
The compounds of the present are helpful in preparations for Combating Lung diseases such as COPD, pulmonary emphysema, cystic Fibrous and acute respiratory distress.Claim 1: wherein is a compound of formula (1) where r u00b9 is selected from Halogen, - CN, - Oh and an alkyl group c u2081 u208b u2084； R u00b2 is selected from Halogen, alkyl c u2081 u208b u2084, haloalquilo c u2081 u208b u2084, - CN, c u2081 u208b u2084 haloalcoxi c u2081 u208b u2084, alkoxy, Nitro,And an - Oh Group； W (i) is a heteroaryl Ring of 5 or 6 members optionally substituted with one or two groups independently selected from Halogen, alkyl - Oh, c u2081 u208b u2084, haloalquilo c u2081 u208b u2084, - CN, c u2081 u208b u2084 alkoxy, Nitro Group, a Group coor u00b2 u2078 nhr u00b9 u2078 -, a -, a Group Co R u00b2 u2079,And a Group conhr u00b9 u2079； (ii) a ring heterocicloalquilo c u2085 u208b u2086 partially unsaturated and optionally substituted with one or two groups independently selected from Halogen, alkyl c u2081 u208b u2084, haloalquilo c u2081 u208b u2084, - CN, - Oh, c u2081 u208b u2084 alkoxy, Nitro and carbonyl Group, a - NHR u00b9 u2078,And a Group conhr u00b9 u2079； or (iii) a phenyl Group optionally substituted with one or two selected groups independently between c u2081 u208b u2084 haloalquilo c u2081 u208b u2084 Halogen, alkyl, Nitro, - CN, - nhr u00b9 u2078, a Group, a Group conhr u00b9 u2079 -, Group - and a or u00b2 u2070； r u00b9 u2078 is Hydrogen, alkyl C - so u2082r u00b2 u00b9 u2081 u208b u2084, a group or a group alquilcarbonilo c u2081 u208b u2084； r u00b2 u00b9 is c u2081 u208b u2084 is Hydrogen or alkyl； r u00b9 u2079 r u00b2 u2070 is Hydrogen, alkyl c u2081 u208b u2084；C u2081 u208b u2084 alkyl group or a - Rent c u2081 u208b u2084 - or u00b2 u00b2； r u00b2 u00b2 is Hydrogen or alkyl c u2081 u208b u2084； r u00b3 is a Group ch u2082 - r u00b2 u00b3； r u00b2 u00b3 is a group selected from Hydrogen, alkyl c u2081 u208b u2084, haloalquilo c u2081 u208b u2084, - cn a
