A method of treating a human subject with a central nervous system injury is provided. Also provided is a method for the reduction or elimination of neuronal cell death, edema or ischemia in a human following a central nervous system injury. Furthermore a method is provided for arresting and/or reversing progression of neurodegeneration in a human following a central nervous system injury. The aforementioned methods comprise a therapy comprising a dosing regime of progesterone or synthetic progestin.
