HPV 45 L1 optimalizált expresszáltatása élesztõben

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

申请号：

HUS1500063

公开号：

HUS1500063I1

申请日:

2015.12.02

申请国别(地区):

HU

年份:

2016

代理人:

摘要：

Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.

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