The present invention relates to a DNA demethylating agent and to a pharmaceutical composition comprising said DNA demethylating agent and at least a pharmaceutical carrier for use in increasing the immune response to papillomavirus (PV) of a subject infected with PV. Further, the present invention relates to the use of a DNA demethylating agent for increasing the immune response to PV of a subject infected with PV. The present invention also relates to a method for increasing the immune response to a PV of a subject infected with said PV, comprising contacting PV-infected cells of said subject infected with PV with a DNA demethylating agent, and, thereby, increasing the immune response to PV of said subject infected with PV. Moreover, the present invention relates to a method of killing a PV-infected cell, comprising contacting said PV-infected cell with a DNA demethylating agent, contacting said PV-infected cell with at least one PV antigen specific T-cell, and, thereby, killing said PV-infected cell.
