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CHIMERIC ANTIGENS FOR BREAKING HOST TOLERANCE TO FOREIGN ANTIGENS
专利权人:
VIREXX MEDICAL CORP.
发明人:
GEORGE, RAJAN,瑞杰 乔治,瑞傑 喬治,TYRRELL, LORNE,罗恩 泰瑞尔,羅恩 泰瑞爾,NOUJAIM, ANTOINE,安东尼 诺杰姆,安東尼 諾傑姆,WANG, DAKUN,达坤 王,達坤 王,MA, ALLAN,艾伦 马,艾倫 馬
申请号:
TW093123603
公开号:
TWI364294B
申请日:
2004.08.06
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
This Hair is bright to disclose the immunization Group with Yu Yin Hair Right antigens into object and method. In particular, The Deng Group at object and the Fang Fa Department anti-Hui of Yin Hair Right by the immunization of Come antigens except host Bian Knowledge As " itself " antigen, and therefore break the tolerance of the antigens such as Bad host Right The. For the main Mian Yi Xi System Zhan Now of Right Su with the chimeric antigen comprising immunization functional domain and Standard Ba Wu Knot conjunction functional domains, it includes a Duan Kang Body segments that wherein The Standard Ba Wu Knot, which close functional domain, can increase the immunization that Strong Right resist outer Come or institutes tolerogenic antigen. Antigen Body liquid and Fine born of the same parents immunization desired by antigen Zhan Now Fine Bao Photo take, Jia Gong And Zhan Now The chimeric antigen , Yin Hair Right are anti-.本發明揭示用於引發對抗抗原之免疫反應的組成物及方法。尤其,該等組成物及方法係引發對抗會被宿主辨識為“自身”抗原之外來抗原的免疫反應,而因此破壞宿主對該等抗原之耐受性。對宿主免疫系統展現以包含免疫反應功能域及標靶物結合功能域之嵌合抗原,其中該標靶物結合功能域包含一段抗體片段,可增強對抗外來或所耐受抗原之免疫反應。抗原展現細胞攝取、加工並展現該嵌合抗原,引發對抗所希望抗原之體液及細胞免疫反應。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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