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ANIMAIS NÃO HUMANOS GENETICAMENTE MODIFICADOS QUE EXPRESSAM EPO HUMANA
专利权人:
REGENERON PHARMACEUTICALS, INC.;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);YALE UNIVERSITY
发明人:
RICHARD FLAVELL,SEAN STEVENS,ANDREW J. MURPHY,MARKUS MANZ,LIANG SHAN
申请号:
PT15756500
公开号:
PT3145307T
申请日:
2015.05.18
申请国别(地区):
PT
年份:
2019
代理人:
摘要:
Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modelling human erythropoiesis and erythrocyte function; in modelling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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