METHODES ET FORMULATIONS POUR LE TRAITEMENT ET/OU LA PROTECTION CONTRE L'INSUFFISANCE HEPATIQUE AIGUE, ET AUTRES TROUBLES CARACTERISES PAR UNE HEPATOTOXICITE
NASSTROM, JACQUES,JACOBSSON, SVEN,HENRIKSEN, DENNIS,VAN ALSTINE, JAMES
申请号：
CA3010915
公开号：
CA3010915A1
申请日:
2017.01.10
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods, formulations and kits for treating and/or protecting against acute liver failure and other hepatotoxicities in an individual employ a combination of a first active agent which replenishes, or decreases a loss of, functional glutathione in the individual, and a second active agent comprising a manganese complex selected from the group consisting of (i) a calcium manganese mixed metal complex of N,N'-bis-(pyridoxal-5-phosphate)-ethylenediamine-N,N'- diacetic acid (DPDP) having a molar ratio of calcium to manganese in a range of from 1 to 10, or a pharmaceutically acceptable salt thereof, (ii) a mixture of manganese DPDP (MnDPDP), or a pharmaceutically acceptable salt thereof, and a non-manganese-containing DPDP compound, or (iii) a mixture of manganese pyridoxyl ethylenediamine (MnPLED), or a pharmaceutically acceptable salt thereof, and a non-manganese-containing pyridoxyl ethylenediamine (PLED) compound.
