Monique Diry;Isabelle De Waziers;Philippe Beaune;Jean-Pierre Flinois;Walid Touati;Patrick Dansette
发明人:
Isabelle De Waziers,Walid Touati,Monique Diry,Jean-Pierre Flinois,Patrick Dansette,Philippe Beaune
申请号：
US14115639
公开号：
US09243231B2
申请日:
2012.05.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant CYP2B6 and NAPDH-cytochrome P450 reductase are provided. The invention also relates to methods of treatment of cancer and the use of said proteins and fusion proteins in the treatment of cancer, in particular via virus-directed enzyme prodrug therapy.
