The present invention relates to combination vaccines comprising a conjugatedpolysaccharide antigen linked to a carrier protein, and wherein the carrierprotein is also present as a free antigen in the vaccine composition,characterised in that the ratio of polysaccharide to protein is from 1:0:3 to1:2. In particular, the vaccine composition of the present invention relatesto a multivalent vaccine, that is a vaccine for the amelioration or treatmentof more than one disease state. The present invention also relates to theproduction and use of such a vaccine in medicine.
