Factor IX with extended half-life period and reduced ligand binding property

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专利权人:

BAXALTA GMBH

发明人:

GERALD SCHRENK,JUERGEN SIEKMANN,PETER TURECEK

申请号：

BR112018011259

公开号：

BR112018011259A2

申请日:

2016.12.05

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

The present invention relates to the materials and method of the oxidized carbohydrate portion that water-soluble polymer is conjugated to treatment albumen matter comprising contacts oxidized carbohydrate portion under conditions of allowing and being conjugated with the water-soluble polymer of activation.More particularly it relates to have the modified recombinant factor VIII (FVIII) for extending half-life period and reduced ligand binding property.

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