INHIBITEURS D'ENDOPEPTIDASE NEUTRE (NEP) ET D'ENDOPEPTIDASE SOLUBLE HUMAINE (HSEP) POUR REDUIRE LES EFFETS NOCIFS D'UNE DEFICIENCE DE PERFUSION D'ORGANES

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专利权人:

FORTY-FOUR PHARMACEUTICALS SP. Z O.O.

发明人:

TURSKI, CHRISTOPHER

申请号：

CA3088969

公开号：

CA3088969A1

申请日:

2019.01.31

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The invention relates to a novel use of benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having both neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP), and endothelin convertase (ECE), inhibitory activity. The compounds of this invention are useful for the preparation of pharmaceutical compositions to reduce harmful effects of symptomless progressive disseminated perfusion deficiency of organs, or parts thereof, that may be suggestive of systemic diseases.

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中国工程科技知识中心

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