An oral transmucosal-extraction device, system and components configured to be inserted or imbedded in an animal or human oral cavity for blood or interstitial fluid biological sample extraction, detection, and analysis. The device includes a receptacle for transmucosal-extraction, and is further configured to interface plurality of customizable function/s and application/s. The functions includes auxiliary body wearables, other medical devices, biologic and blood component detection, analysis, data collections, communication network, diagnostics for enhanced therapeutics and athletic performance. A part or entire device can also be configured to be inserted into a “reader,” which is external to the oral cavity. The reader is either “smart” or connected to a “smart device such as smart phone, and is configured to contain one or more sensors. The invention provides innovative information systems, and methods involving the aforedescribed devices, information available from blood, interstitial-fluids, biologics using transmucosal-extraction-sensor devices in the oral cavity and auxiliary devices.
