Doyle, Anthony Gerard,Tomlinson, Ian M,Jennings, Philip Anthony,Woolven, Benjamin P,Lee, Jennifer A
申请号：
AU2006326937
公开号：
AU2006326937B2
申请日:
2006.12.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention provides a recombinant domain antibody (dAb) which binds to human TNF-α, the dAb comprising an immunoglobulin heavy or light chain variable domain, wherein said variable domain comprises at least one complementarity determining region (CDR) having a sequence derived from a New World primate wherein the CDR is selected from the group consisting of YAATKLQS (SEQ ID No: l), YEASSLQS (SEQ ID No:2), YEASKLQS (SEQ ID No:3) and YSASNLET (SEQ ID No:4). The recombinant domain antibody is used to detect human TNF-α in a sample and to treat a disorder characterized by human TNF-α activity.
