A connective tissue modification cuff can be applied around a portion of the body and drawn tight. Integrated within the portion of the cuff that is pressed against the body is a plurality of variable compression beads. These variable compression beads comprise half spherical beads, half prolate spheroid beads, half oblate spheroid beads, or other similarly rounded structures that provide variably increasing pressure towards their high-points and gradually reduced pressure towards their low points. The cuff can be tightened down via a tensioning system that allows even tightening in small increments. Once in place, the person then stretches or uses the arm in order to apply the variable compression beads to the connective tissue under use. Such application works on the underlying connective tissue to reduce the pain and associated problems.