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PHARMACEUTICAL AEROSOL COMPOSITION OF PROTEAZ INHIBITORS WITH OZONE-SAVING PROPELLANT AND ITS PRODUCTION
专利权人:
Жирнов Олег Петрович (RU)
发明人:
Жирнов Олег Петрович (RU)
申请号:
RU2011144624/15
公开号:
RU2011144624A
申请日:
2011.11.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The pharmaceutical aerosol composition of the protease inhibitor with ozone-saving propellant, characterized in that an aqueous solution of the active substance from the group of protease inhibitors containing 0.05-250 mg of the protease inhibitor per ml of solution is sequentially mixed with the ingredients of a three-component push mixture, namely: glycerol, ethanol and a water-insoluble ozone-saving propellant with a ratio of the aqueous phase and a three-component mixture of 0.5-5 and 95-99.5 vol.%, respectively, and create a homogeneous aerosol composition that allows generating pharmaceutical aerosol of the active protease inhibitor due to the buoyancy of the propellant when spraying the resulting composition from an aerosol device equipped with an exhaust valve. 2. The mixture according to claim 1, characterized in that the aqueous solution of the protease inhibitor is sequentially mixed with components of the ejection system - glycerol, ethanol and a fluorine-containing propellant 134A, taken in a volume ratio of 1-7: 3-13: 80-96%, respectively. 3. A mixture according to claim 1, characterized in that the active substance selected from the group of protease inhibitors of protein and polypeptide nature is aprotinin, α 2-antiplasmin, α-1 antitrypsin, antitrypsin, cystatin, mainly aprotinin, or a combination thereof. A mixture according to claim 1, characterized in that the active substance is selected from the group of antiprotease oligopeptides consisting of two or more amino acid residues and their modified derivatives. The mixture according to claim 1, containing one or more organoleptic additives, from the group of vegetable oils, including peppermint oil, aromatic mint, menthol oil in an amount1. Фармацевтический аэрозольный состав ингибитора протеаз с озонсберегающим пропеллентом, отличающийся тем, что водный раствор активного вещества из группы ингибиторов протеаз, содержащий 0,05-250 мг протеазного ингибитора на мл раствора, последовательно смешиваю
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