THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;ACCELERON PHARMA, INC.
发明人:
Paul B. YU,Asya GRINBERG,Dianne S. SAKO,Roselyne CASTONGUAY,Rita STEEVES,Ravindra KUMAR
申请号：
US16851287
公开号：
US20200323955A1
申请日:
2020.04.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In some aspects, the invention teaches pharmaceutical compositions that include a TGF-β ligand trap, and methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-β signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-β ligand trap to reduce right ventricular systolic pressure in a subject.
