A blood vessel optical fiber guide wire includes at least one of optical fiber core wire, a wire wrapping layer and a hydrophilic coating capable of improving compatibility with body liquids and reducing the resistance. The optical fiber core wire is disposed in a core of the optical fiber guide wire. The wire wrapping layer is formed from at least one of winding wire or winding sheet wrapping outside of the optical fiber core wire. The hydrophilic coating is coated outside of the wire wrapping layer. The optical fiber guide wire may enter a predetermined position in artery blood vessel of human body. The light can be guided into and/or guided out of a location of lesion so as to achieve the photodynamic treatment of diseases such as tumor in vivo. The need to diagnosis and treatment in the field including biology and medical treatment can be met.
