ABSTRACT - 602076 The disclosure relates to a process for extracting and isolating constituents from cellulosic material, which comprises the steps of: (a) contacting the cellulosic material with a supercritical fluid (preferably carbon dioxide) under conditions to provide an extract, (wherein the cellulosic material is preferably derived from mullein, cloves, mint, tea, Eucalyptus, or camomile or tobacco) (b) removing the insoluble material from the extract and (c) fractionating the extract by distillation under depressed or reduced pressure to provide one or more isolated constituents (wherein the constituents isolated according to the process are substantially pure, or have a reduced level of one or more of nicotine, one or more nitrosamines, or benzo[a]pyrene in comparison to the cellulosic material from which the constituents were isolated, or from the cellulosic material from which they were isolated when concentrated and/or processed to a comparable extent).
