An arrangement for manipulating a medical device to be inserted into the body of a patient, the arrangement comprising: a drive element to be driven by a motor a control element for controlling at least one motion of the medical device a transmission arrangement for transmitting motion from the drive element to the control element, the transmission arrangement comprising first and second members which are frictionally engaged with one another so that motion may be transmitted from one to the other and a manual manipulation control which may be grasped by a user to move the medical device manually while the first and second members remain in frictional engagement with one another.