GORDON D. WEBSTER,SUZANNE P. MCKENZIE,KIN-MING LO,PASCAL ANDRE STEIN
申请号：
PT06846989
公开号：
PT1966238E
申请日:
2006.12.20
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
